Associate Professor

zmchen@dicp.ac.cn

Dr. Zhaoming Chen received her B.Sc. degree from Liaoning University in 2018, her M.Sc. degree in Polymer Chemistry and Physics from Nankai University in 2021, and Ph.D. degree in Analytical Chemistry from Nankai University in 2025. After graduation, she was appointed as an Outstanding Young Doctoral Talent and Associate Research Fellow at the Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS). Her research focuses on bioluminescence super-resolution imaging and the construction and application of organ/tumor-targeted mRNA delivery. Dr. Chen has published 9 papers in leading journals, including JACS and Angew, and has applied for 2 invention patents.

EDUCATION and PROFESSIONAL EXPERIENCE：

2014.09-2018.06：B.Sc. in Materials Chemistry, Liaoning University (LNU),

2018.09-2021.07：M.Sc. in Polymer Chemistry and Physics, Nankai University (NKU),

2021.09-2025.06：Ph.D. in Analytical Chemistry, Nankai University (NKU),

2026.02-Present：Associate Professor, Dalian Institute of Chemical Physics, CAS.

REPRESENTATIVE PUBLICATIONS：

[1] Zhaoming Chen#, Zhifeng Jieyu Yang#, Bingbing Zheng, Yuexia Yang, Xinyu Qiu, Hao Zhou, Rui Wang, Prof. Dr. Hu Xiong*. Thiourea-Functionalized Ionizable Lipids Enable Systemic mRNA Delivery to Secondary Lymphoid Organs and Dual-Modal Lymphatic Metastasis Imaging. Angew. Chem. Int. Ed., 2026, e23579.

[2] Zhaoming Chen, Yuexia Yang, Xinyu Qiu, Hao Zhou, Rui Wang, Hu Xiong*. Crown-like Biodegradable Lipids Enable Lung-Selective mRNA Delivery and Dual-Modal Tumor Imaging In Vivo. , J. Am. Chem. Soc., 2024, 146(49), 34209-34220.

[3] Zhaoming Chen, Yuexia Yang, Yang Tian, Jieyu Yang, Hu Xiong*. Diagnosis of Nonalcoholic Fatty Liver Disease via a H2S-Responsive Bioluminescent Probe Combined with Firefly Luciferase mRNA Delivery.  Anal. Chem., 2024, 96(22), 9236-9243.

[4] Zhaoming Chen, Yang Tian, Jieyu Yang, Fapu Wu, Senyao Liu, Wenwen Cao, Weijia Xu, Tao Hu, Daniel J Siegwart, Hu Xiong*. Modular Design of Biodegradable Ionizable Lipids for Improved mRNA Delivery and Precise Cancer Metastasis Delineation In Vivo., J. Am. Chem. Soc., 2023, 145(44), 24302-24314.